
Polynucleotides
Polynucleotides are advanced regenerative injectable treatments designed to stimulate cellular repair, improve skin quality, and support long term tissue regeneration. They work at a deeper biological level to enhance collagen production, improve elasticity, strengthen the skin barrier, and restore overall skin vitality.
A consultation is required before any treatment at Good Things Clinic, view our consultation options here.
At Good Things Clinic, I only use the highest quality medical grade products to ensure safety, efficacy, and optimal outcomes. The polynucleotide treatments offered in clinic include Plinest, Newest, and Plinest Eye, each carefully selected to address specific skin concerns and treatment areas.
Every treatment begins with a detailed consultation to assess suitability, understand your concerns, and determine which formulation is most appropriate for your skin.
How Polynucleotides Work
Polynucleotides are highly purified DNA fragments that support tissue regeneration and cellular repair. Once administered into the skin, they stimulate fibroblast activity, encourage collagen and elastin production, improve microcirculation, and enhance hydration at a cellular level.
This regenerative action helps to improve skin thickness, texture, elasticity, and resilience. The result is stronger, healthier skin that appears smoother, brighter, and more refined over time.
In addition to their regenerative benefits, polynucleotides can also be used strategically to prepare the skin prior to other treatments such as chemical peels or microneedling. By strengthening the skin barrier and improving cellular function, they enhance skin resilience and may support improved overall treatment outcomes. They may also form part of a treatment plan for certain pigmentation concerns where improving skin quality and supporting tissue repair is beneficial.
Our polynucleotide treatments
Plinest
Plinest is a highly purified polynucleotide treatment focused on regenerative repair and collagen stimulation. It is particularly suited to improving skin firmness, elasticity, and overall texture in areas where thinning skin, loss of resilience, or early laxity are concerns.
Plinest works progressively to strengthen the skin structure, making it an excellent option for individuals seeking subtle, natural improvement in skin density and quality without altering facial features.
Newest
Newest combines polynucleotides with hyaluronic acid to deliver both regenerative stimulation and enhanced hydration. The addition of hyaluronic acid provides immediate moisture support while the polynucleotides work to stimulate collagen and elastin production.
This dual action approach makes Newest particularly suitable for individuals experiencing dehydration alongside early skin laxity, fine lines, or dullness. It improves skin density and elasticity while restoring hydration and luminosity.
Plinest Eye
Plinest Eye is specifically formulated for the delicate under eye and eyelid area. The skin in this region is thinner and more prone to crepiness, fine lines, and early laxity. It is particularly beneficial for individuals concerned about tired looking eyes, under eye bags, and changes in colour beneath the eyes that can contribute to a darker appearance.
By stimulating collagen production, improving microcirculation, and supporting tissue repair, Plinest Eye helps strengthen and revitalise this fragile area. It may also form part of a treatment plan where pigmentation or uneven tone beneath the eyes is a concern, helping to improve overall skin quality and brightness over time.
Rather than adding volume, it supports regeneration and improves the appearance of the under eye area in a subtle and natural way.
Benefits of Polynucleotides
- Improves skin elasticity and firmness
- Supports collagen and elastin production
- Enhances hydration and skin barrier function
- Improves crepey or thinning skin
- Reduces the appearance of fine lines
- Supports under eye rejuvenation
- Improves overall skin texture and tone
- Encourages tissue repair and regeneration
- Supports skin preparation prior to advanced treatments
- May assist as part of a treatment plan for certain pigmentation concerns
Who Is It Suitable For
Polynucleotides are particularly suitable for individuals experiencing early to moderate skin laxity, dull or tired looking skin, thinning or fragile skin, under eye crepiness, fine lines, or loss of skin density. They are also ideal for those seeking regenerative improvement rather than structural volumisation.
They may also be recommended as part of a preparatory treatment plan before more intensive skin procedures, or where strengthening and improving skin resilience is a priority.
Suitability will always be confirmed following consultation and medical assessment.
Patient information
Frequently asked questions
What is the difference between Newest and Plinest?
Both are polynucleotide treatments designed to stimulate regeneration. Newest also includes hyaluronic acid, which adds hydration alongside the regenerative effect. The most suitable option will be recommended based on your skin concerns, treatment area, and desired outcomes.
Is polynucleotide treatment suitable for the under eye area?
Yes, Plinest Eye is specifically formulated for delicate under eye and eyelid treatment, helping to improve crepiness, fine lines, and skin quality in this sensitive area.
How many sessions will I need?
A course of 3 treatments is typically recommended for optimal results. Your personalised plan will be discussed during consultation.
When will I see results?
Results develop progressively as collagen stimulation and tissue repair occur. Improvements in skin quality become more noticeable over several weeks.
Can polynucleotides be combined with other treatments?
Yes, they can be incorporated into a broader regenerative or skin health plan. This will be discussed during consultation to ensure treatments complement each other safely and effectively.
Is there downtime?
Downtime is minimal. Mild swelling or small injection marks may be visible temporarily and usually settle within a few days.
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Book your Polynucleotides consultation
Every treatment starts with a personalised consultation with Abigail, so your plan is safe, suitable and built around you.
Our New Website Is Here!
Celebrate With £25 Off!
To celebrate the launch of our new website, we're offering £25 off your next eligible treatment, with no minimum spend!
New to Good Things Clinic? Your journey begins with a personalised consultation, where we'll discuss your concerns and recommend treatments tailored to your individual needs.
Following your consultation, you can enjoy £25 off an eligible treatment booked between 18 October and 15 November 2026.
Terms and Conditions: Offer valid for new treatment bookings made between 18 October and 15 November 2026 inclusive. Treatments may take place after this period. New patients must complete an initial consultation before treatment. The discount applies to eligible treatments only, not consultation fees. Excludes previously booked appointments, products, prescription-only treatments and other promotions. One redemption per patient. Subject to clinical suitability. Discount cannot exceed the treatment price.